The "Shenzhen-based research team examined the role that nicotine may play in rebalancing NAD+ levels to affect aging. After low-dose nicotine administration in drinking water (2 μg/mL) from 6 to 12 months, NAMPT activity and NAD+ levels were significantly restored in the brain, heart, and muscle tissues of middle-aged mice, as well as in aged mouse brain cells cultured in lab dishes. High-dose nicotine, on the other hand, had a negative effect on NAMPT activity and NAD+ levels."
Translating Mouse Nicotine Dosing to Human Patch Use
Mouse Model Dosing
Mice are dosed with nicotine at 2 μg/mL in drinking water.
Mice consume 4–7 mL of water per day, resulting in a nicotine intake of 8–14 μg/day.
Calculate Human Equivalent Dose (HED)
Convert mouse dose to mg/kg:
Low dose: 0.32 mg/kg
High dose: 0.56 mg/kg
Adjust for human body weight (70 kg) using allometric scaling:
HED range: 1.8–3.15 mg/day.
Determine Nicotine Patch Wear Time
A 7 mg nicotine patch delivers 7 mg over 24 hours (0.292 mg/hour).
Halving the patch results in a release of 3.5 mg over 24 hours (0.146 mg/hour).
Wear Time for Desired Dose
For 1.8 mg/day → Wear the half patch for ~12 hours.
For 3.15 mg/day → Wear the half patch for ~22 hours.
Study Shows Low-Dose Nicotine Can Protect the Brain from Aging
Low-dose nicotine in aging mice improves NAD+ synthesis, enhances brain cell formation, and ameliorates cognitive deficits, suggesting neuroprotect...