@Carlton Gibson was right, we can get comparable performance to Fast API with msgspec validation..

GitHub

GitHub - FarhanAliRaza/django-rapid: Msgspec based serialization for django.

Msgspec based serialization for django. Contribute to FarhanAliRaza/django-rapid development by creating an account on GitHub.

I created this basic validation library for JSON validation and serialization, and response validation. Its performance is comparable to Fast Api. I was able to outcompete Fast api, but that required some black magic, like a custom HttpResponse.